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research article

Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering

Mathieu, Laurence M.
•
Mueller, Thomas L.
•
Bourban, Pierre-Etienne  
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2006
Biomaterials

Bone is a complex porous composite structure with specific characteristics such as viscoelasticity and anisotropy, both in morphology and mechanical properties. Bone defects are regularly filled with artificial tissue grafts, which should ideally have properties similar to those of natural bone. Open cell composite foams made of bioresorbable poly(L-lactic acid) (PLA) and ceramic fillers, hydroxyapatite (HA) or b-tricalcium phosphate (b-TCP), were processed by supercritical CO2 foaming. Their internal 3Dstructure was then analysed by micro-computed tomography (mCT), which evidenced anisotropy in morphology with pores oriented in the foaming direction. Furthermore compressive tests demonstrated anisotropy in mechanical behaviour, with an axial modulus up to 1.5 times greater than the transverse modulus. Composite scaffolds also showed viscoelastic behaviour with increased modulus for higher strain rates. Such scaffolds prepared by gas foaming of polymer composite materials therefore possess suitable architecture and properties for bone tissue engineering applications.

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Type
research article
DOI
10.1016/j.biomaterials.2005.07.015
Web of Science ID

WOS:000234095800011

Author(s)
Mathieu, Laurence M.
Mueller, Thomas L.
Bourban, Pierre-Etienne  
Pioletti, Dominique P.  
Müller, Ralph
Manson, Jan-Anders  
Date Issued

2006

Published in
Biomaterials
Volume

27

Issue

6

Start page

905

End page

916

Subjects

Composite

•

Scaffold

•

Compression

•

Micro CT

•

Anisotropy

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
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LBO  
Available on Infoscience
March 27, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/36411
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