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  4. Mechanical characterization and constitutive law of porcine urethral tissues: a hyperelastic fiber model based on a physical approach
 
research article

Mechanical characterization and constitutive law of porcine urethral tissues: a hyperelastic fiber model based on a physical approach

De Menech, Quentin  
•
Osorio Salazar, Andres  
•
Bourgogne, Quentin
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April 10, 2005
Biomechanics and modeling in mechanobiology

Lower urinary tract symptoms (LUTS), particularly urinary incontinence (UI), represent a significant global health challenge, affecting millions of patients worldwide. The artificial urinary sphincter (AUS) remains one of the most effective intervention for severe UI, with its design relying on a detailed understanding of the urethral biomechanics. Given the ethical and logistical constraints of using human tissue, porcine urethras, which share anatomical and mechanical similarities with human urethras, are widely employed in preclinical studies. This study investigates the uniaxial mechanical characterization of porcine urethral tissue under controlled conditions. Fresh porcine urethral samples were subjected to uniaxial tensile testing along both the longitudinal and circumferential directions to characterize their anisotropic mechanical properties. Experimental results were compared with existing datasets to validate findings. Additionally, conventional hyperelastic models were assessed to fit experimental results, and a novel anisotropic constitutive model with physical parameters was developed. This fiber model, which incorporates fiber modulus, volume, and orientation, uses a single set of parameters to predict behavior in both directions. It demonstrated improved accuracy, reaching the performance of the Gasser-Ogden-Holzapfel (GOH) model, with root mean square errors (RMSEs) of 9.24% and 12.98% in the circumferential and longitudinal directions, respectively. In contrast, the Yeoh and Ogden models were unable to fit both directions using a single set of parameters, yielding RMSEs values exceeding 30%. With its enhanced physical relevance, the fiber model having a more physical meaning holds promise for applications in the biomechanical analysis of fiber-composed soft tissues.

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Type
research article
DOI
10.1007/s10237-025-01951-w
Author(s)
De Menech, Quentin  

École Polytechnique Fédérale de Lausanne

Osorio Salazar, Andres  

École Polytechnique Fédérale de Lausanne

Bourgogne, Quentin

Université de Lorraine

Civet, Yoan  

École Polytechnique Fédérale de Lausanne

Baldit, Adrien

Université de Lorraine

Perriard, Yves  

École Polytechnique Fédérale de Lausanne

Date Issued

2005-04-10

Publisher

American Psychological Association (APA)

Published in
Biomechanics and modeling in mechanobiology
Issue

2025

Subjects

Anisotropy

•

Biomechanics

•

Ex vivo testing

•

Hyperelastic models

•

Urinary incontinence

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LAI  
CAM  
FunderFunding(s)Grant NumberGrant URL

Werner Siemens-Stiftung

École Polytechnique Fédérale de Lausanne

Available on Infoscience
April 10, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/249044
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