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  4. Near-wall hemodynamic parameters quantification in in vitro intracranial aneurysms with 7 T PC-MRI
 
research article

Near-wall hemodynamic parameters quantification in in vitro intracranial aneurysms with 7 T PC-MRI

Sache, Antoine  
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Reymond, Philippe
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Brina, Olivier
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April 19, 2023
Magnetic Resonance Materials In Physics Biology And Medicine

ObjectiveWall shear stress (WSS) and its derived spatiotemporal parameters have proven to play a major role on intracranial aneurysms (IAs) growth and rupture. This study aims to demonstrate how ultra-high field (UHF) 7 T phase contrast magnetic resonance imaging (PC-MRI) coupled with advanced image acceleration techniques allows a highly resolved visualization of near-wall hemodynamic parameters patterns in in vitro IAs, paving the way for more robust risk assessment of their growth and rupture.Materials and methodsWe performed pulsatile flow measurements inside three in vitro models of patient-specific IAs using 7 T PC-MRI. To this end, we built an MRI-compatible test bench, which faithfully reproduced a typical physiological intracranial flow rate in the models.ResultsThe ultra-high field 7 T images revealed WSS patterns with high spatiotemporal resolution. Interestingly, the high oscillatory shear index values were found in the core of low WSS vortical structures and in flow stream intersecting regions. In contrast, maxima of WSS occurred around the impinging jet sites.ConclusionsWe showed that the elevated signal-to-noise ratio arising from 7 T PC-MRI enabled to resolve high and low WSS patterns with a high degree of detail.

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Type
research article
DOI
10.1007/s10334-023-01082-2
Web of Science ID

WOS:000974278400002

Author(s)
Sache, Antoine  
Reymond, Philippe
Brina, Olivier
Jung, Bernd
Farhat, Mohamed  
Vargas, Maria Isabel
Date Issued

2023-04-19

Publisher

SPRINGER

Published in
Magnetic Resonance Materials In Physics Biology And Medicine
Subjects

Radiology, Nuclear Medicine & Medical Imaging

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intracranial aneurysms

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7 t phase contrast mri

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hemodynamics

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wall shear stress

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in vitro models

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phase-contrast mri

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4-dimensional flow mri

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shear-stress

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noise ratio

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blood-flow

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image quality

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time

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velocity

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fluid

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visualization

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SCI-STI-MF  
Available on Infoscience
May 22, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/197752
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