A highly integrated system for remote monitoring of several human metabolites is proposed. It is obtained by integrating several components, such as: bio-probes, carbon nanotubes, micro-fabricated gold-electrodes, temperature and pH sensors, extremely small CMOS IC and multilayer coil for remote powering data acquisition and transmission. The entire system has final sizes of only 2.2 mm in width and thick and it is long 1.5 cm. In this paper, results on sensors micro-fabrication, sensing tests, IC design, and power transmission are presented. These results confirmed that the proposed approach is suitable for minimally invasive monitoring of multi-metabolites in humans.