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  4. Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib
 
review article

Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib

Hantschel, Oliver  
•
Rix, Uwe
•
Superti-Furga, Giulio
2008
Leukemia & lymphoma

Following the initial success of imatinib as frontline therapy for chronic myeloid leukemia (CML), several second-generation therapeutics have been developed with increased potency and the ability to inhibit the majority of imatinib-resistant mutations. Here, we review the current knowledge about the target specificity of the two new inhibitors nilotinib and dasatinib in comparison to imatinib, including the recent large-scale chemical proteomics screens.

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