This multi-partner-project contribution introduces the midway results of the Horizon 2020 FVLLMONTI project. In this project we develop a new and ultra-efficient class of ANN accelerators, the neural network compute cube (N2C2), which is specifically designed to execute complex machine learning tasks in a 3D technology, in order to provide the high computing power and ultra-high efficiency needed for future edgeAI applications. We showcase its effectiveness by targeting the challenging class of Transformer ANNs, tailored for Automatic Speech Recognition and Machine Translation, the two fundamental components of speech-to-speech translation. To gain the full benefit of the accelerator design, we develop disruptive vertical transistor technologies and execute design-technology-co-optimization (DTCO) loops from single device, to cell and compute cube level. Further, a hardware-software-co-optimization is executed, e.g. by compressing the executed speech recognition and translation models for energy efficient executing without substantial loss in precision.