Restoring natural sensation via neuroprosthetics relies on the possibility of encoding complex and nuanced information. For example, an ideal brain–machine interface with sensory feedback would provide the user with sensation about movement, pressure, curvature, texture, etc. Despite advances in neural interfaces that allow for complex stimulation patterns (e.g., multisite stimulation or the possibility of targeting a precise neural ensemble), a key question remains: How can we best exploit the potential of these technologies? The increasing number of electrodes coupled with more parameters being explored leads to an exponential increase in the number of possible combinations, making a brute-force approach, such as systematic search, impractical. This Perspective outlines three different optimization frameworks—namely, the explicit, physiological, and self-optimized methods—allowing one to potentially converge faster toward effective parameters. Although our focus will be on the somatosensory system, these frameworks are flexible and applicable to various sensory systems (e.g., vision) and stimulator types.