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  4. Global and stage specific patterns of krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells
 
research article

Global and stage specific patterns of krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells

Corsinotti, Andrea  
•
Kapopoulou, Adamandia  
•
Gubelmann, Carine  
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2013
PloS One

Highly coordinated transcription networks orchestrate the self-renewal of pluripotent stem cell and the earliest steps of mammalian development. KRAB-containing zinc finger proteins represent the largest group of transcription factors encoded by the genomes of higher vertebrates including mice and humans. Together with their putatively universal cofactor KAP1, they have been implicated in events as diverse as the silencing of endogenous retroelements, the maintenance of imprinting and the pluripotent self-renewal of embryonic stem cells, although the genomic targets and specific functions of individual members of this gene family remain largely undefined. Here, we first generated a list of Ensembl-annotated KRAB-containing genes encoding the mouse and human genomes. We then defined the transcription levels of these genes in murine early embryonic cells. We found that the majority of KRAB-ZFP genes are expressed in mouse pluripotent stem cells and other early progenitors. However, we also identified distinctively cell- or stage-specific patterns of expression, some of which are pluripotency-restricted. Finally, we determined that individual KRAB-ZFP genes exhibit highly distinctive modes of expression, even when grouped in genomic clusters, and that these cannot be correlated with the presence of prototypic repressive or activating chromatin marks. These results pave the way to delineating the role of specific KRAB-ZFPs in early embryogenesis.

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Type
research article
DOI
10.1371/journal.pone.0056721
Web of Science ID

WOS:000316658800030

Author(s)
Corsinotti, Andrea  
Kapopoulou, Adamandia  
Gubelmann, Carine  
Imbeault, Michael
de Sio, Santoni
Francesca, R.
Rowe, Helen M.
Mouscaz, Yoann  
Deplancke, Bart  
Trono, Didier  
Date Issued

2013

Publisher

Public Library of Science

Published in
PloS One
Volume

8

Issue

2

Article Number

e56721

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LVG  
UPDEPLA  
Available on Infoscience
March 4, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/90078
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