We present a cost-effective rehabilitation system based on videogames and multimodal recordings of physiological signals. The system targets patients with sensory-motor impairments resulting from lesions of the central nervous system (e.g., due to stroke or traumatic injuries). It relies on a wireless low-cost hybrid interface combining a consumer-level electroencephalographic (EEG) device and the Kinect sensor to record the motion capture information. Thus providing quantitative physiological measures to support medical evaluations and improve the personalization of health service. Furthermore, through the design of specialized videogames for rehabilitation, we aim at increasing the patient’s motivation, potentially improving the service quality and the recovery process. The system is currently being used in a rehabilitation center in Colombia by patients with upper limb paralysis and balance disorders after stroke or traumatic injuries. Initial results show significant improvements in the mobility of affected joints, improved adherence to treatments by patients, and high acceptability by therapists and end-users.