research article
Effects of methotrexate on transfected DNA stability in mammalian cells
The chromosomal locations, amounts, and level of expression of transfected, amplified c-myc and dihydrofolate reductase sequences were measured in cells cultured in the presence and absence of methotrexate. These studies show that the location and amount of transfected sequences, as well as the level of expression, were more variable when the cells were cultured in methotrexate.
Type
research article
PubMed ID
2403643
Author(s)
Date Issued
1990
Published in
Volume
10
Issue
1
Start page
401
End page
4
Subjects
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Note
Biomedical Sciences Division, Lawrence Livermore National Laboratory, Livermore, California 94550.
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
June 5, 2007
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