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  4. Real-time Protein Aggregation Monitoring based on a Simultaneous Light Scattering Investigation and a Bloch Surface Wave-based Approach
 
conference paper

Real-time Protein Aggregation Monitoring based on a Simultaneous Light Scattering Investigation and a Bloch Surface Wave-based Approach

Santi, Sara  
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Barakat, Elsie  
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Neier, Reinhard
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Mohseni, H
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Agahi, Mh
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2015
Biosensing And Nanomedicine Viii
Conference on Biosensing and Nanomedicine VIII

We present a study of the dynamics of protein aggregation using a Bloch surface wave (BSW) label-free sensing scheme. In a previous work, we demonstrated the ability to detect the early dynamic events of fibrillogenesis of amyloid beta-peptides (A beta), linked to Alzheimer's Disease. Here, we demonstrate the efficacy of the BSW sensor by describing a simultaneous light scattering measurement, with the purpose of real-time monitoring the size change of the A beta aggregates, throughout fibrillization.

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