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research article

Haematopoietic stem cell niche in Drosophila

Koch, U.  
•
Radtke, F.  
2007
Bioessays

Development and homeostasis of the haematopoietic system is dependent upon stem cells that have the unique ability to both self-renew and to differentiate in all cell lineages of the blood. The crucial decision between haematopoietic stem cell (HSC) self-renewal and differentiation must be tightly controlled. Ultimately, this choice is regulated by the integration of intrinsic signals together with extrinsic cues provided by an exclusive microenvironment, the so-called haematopoietic niche. Although the haematopoietic system of vertebrates has been studied extensively for many decades, the specification of the HSC niche and its signals involved are poorly understood. Much of our current knowledge of how niches regulate long-term maintenance of stem cells is derived from studies on Drosophila germ cells. Now, two recently published studies by Mandal et al.1 and Krezmien et al.2 describe the Drosophila haematopoietic niche and signal transduction pathways that are involved in the maintenance of haematopoietic precursors. Both reports emphasize several features that are important for controlling stem cell behavior and show parallels to both the vertebrate haematopoietic niche as well as the Drosophila germline stem cell niches in ovary and testis. The findings of both papers shed new light on the specific interactions between haematopoietic progenitors and their microenvironment

  • Details
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Type
research article
DOI
10.1002/bies.20613
Web of Science ID

WOS:000248514000001

PubMed ID

17620327

Author(s)
Koch, U.  
Radtke, F.  
Date Issued

2007

Published in
Bioessays
Volume

29

Issue

8

Start page

713

End page

716

Note

Swiss Institute for Experimental Cancer Research (ISREC), Ecole Polytechnique Fedarale de Lausanne (EPFL), Chemin des Boveresses 155, 1066 Epalinges, Switzerland.

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPRAD  
Available on Infoscience
July 31, 2007
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/9965
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