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research article

Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept

Uslu, Ece  
•
Rana, Vijay Kumar  
•
Anagnostopoulos, Sokratis  
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July 21, 2023
Iscience

Tracheomalacia (TM) is a condition characterized by a weak tracheal cartilage and/or muscle, resulting in excessive collapse of the airway in the newborns. Current treatments including tracheal reconstruction, tracheoplasty, endo- and extra-luminal stents have limitations. To address these limitations, this work proposes a new strategy by wrapping an adhesive hydrogel patch around a malacic trachea. Through a numerical model, first it was demonstrated that a hydrogel patch with sufficient mechanical and adhesion strength can preserve the trachea's physiological shape. Accordingly, a new hydrogel providing robust adhesion on wet tracheal surfaces was synthesized employing the hydroxyethyl acrylamide (HEAam) and polyethylene glycol methacrylate (PEGDMA) as main polymer network and crosslinker, respectively. Ex vivo experiments revealed that the adhesive hydrogel patches can restrain the collapsing of malacic trachea under negative pressure. This study may open the possibility of using an adhesive hydrogel as a new approach in the difficult clinical situation of tracheomalacia.

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Type
research article
DOI
10.1016/j.isci.2023.107168
Web of Science ID

WOS:001056433900001

Author(s)
Uslu, Ece  
Rana, Vijay Kumar  
Anagnostopoulos, Sokratis  
Karami, Peyman  
Bergadano, Alessandra
Courbon, Cecile
Gorostidi, Francois
Sandu, Kishore
Stergiopulos, Nikolaos  
Pioletti, Dominique P.  
Date Issued

2023-07-21

Publisher

CELL PRESS

Published in
Iscience
Volume

26

Issue

7

Article Number

107168

Subjects

Multidisciplinary Sciences

•

Science & Technology - Other Topics

•

cross-linking

•

airway

•

tracheobronchomalacia

•

collapse

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LBO  
Available on Infoscience
September 25, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/200981
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