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  4. Coding and Decoding with Adapting Neurons: A Population Approach to the Peri-Stimulus Time Histogram
 
research article

Coding and Decoding with Adapting Neurons: A Population Approach to the Peri-Stimulus Time Histogram

Naud, Richard  
•
Gerstner, Wulfram  
2012
Plos Computational Biology

The response of a neuron to a time-dependent stimulus, as measured in a Peri-Stimulus-Time-Histogram (PSTH), exhibits an intricate temporal structure that reflects potential temporal coding principles. Here we analyze the encoding and decoding of PSTHs for spiking neurons with arbitrary refractoriness and adaptation. As a modeling framework, we use the spike response model, also known as the generalized linear neuron model. Because of refractoriness, the effect of the most recent spike on the spiking probability a few milliseconds later is very strong. The influence of the last spike needs therefore to be described with high precision, while the rest of the neuronal spiking history merely introduces an average self-inhibition or adaptation that depends on the expected number of past spikes but not on the exact spike timings. Based on these insights, we derive a 'quasi-renewal equation' which is shown to yield an excellent description of the firing rate of adapting neurons. We explore the domain of validity of the quasi-renewal equation and compare it with other rate equations for populations of spiking neurons. The problem of decoding the stimulus from the population response (or PSTH) is addressed analogously. We find that for small levels of activity and weak adaptation, a simple accumulator of the past activity is sufficient to decode the original input, but when refractory effects become large decoding becomes a non-linear function of the past activity. The results presented here can be applied to the mean-field analysis of coupled neuron networks, but also to arbitrary point processes with negative self-interaction.

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Type
research article
DOI
10.1371/journal.pcbi.1002711
Web of Science ID

WOS:000310568800012

Author(s)
Naud, Richard  
Gerstner, Wulfram  
Date Issued

2012

Publisher

Public Library of Science

Published in
Plos Computational Biology
Volume

8

Issue

10

Article Number

e1002711

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCN  
Available on Infoscience
October 5, 2012
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/85983
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