Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and Its Subsequent Transformation to Macrocyclodepsipeptide

Pirali, Tracey; Tron, Gian Cesare; Masson, Geraldine; Zhu, Jieping

doi:10.1021/ol7024372

research article

Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and Its Subsequent Transformation to Macrocyclodepsipeptide

Pirali, Tracey

•

Tron, Gian Cesare

•

Masson, Geraldine

2007

Organic Letters

A three-component reaction of an alpha ,alpha -disubstituted alpha -isocyanoacetamide, an aldehyde and an amino alc. afforded 5-iminooxazolines, which, upon sapon., cyclized under acidic conditions to provide the macrocyclodepsipeptides in good overall yields. [on SciFinder (R)]