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research article

Architecture and coevolution of allosteric materials

Yan, Le
•
Ravasio, Riccardo  
•
Brito, Carolina
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2017
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)

We introduce a numerical scheme to evolve functional elastic materials that can accomplish a specified mechanical task. In this scheme, the number of solutions, their spatial architectures, and the correlations among them can be computed. As an example, we consider an "allosteric" task, which requires the material to respond specifically to a stimulus at a distant active site. We find that functioning materials evolve a less-constrained trumpet-shaped region connecting the stimulus and active sites, and that the amplitude of the elastic response varies nonmonotonically along the trumpet. As previously shown for some proteins, we find that correlations appearing during evolution alone are sufficient to identify key aspects of this design. Finally, we show that the success of this architecture stems from the emergence of soft edge modes recently found to appear near the surface of marginally connected materials. Overall, our in silico evolution experiment offers a window to study the relationship between structure, function, and correlations emerging during evolution.

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Type
research article
DOI
10.1073/pnas.1615536114
Web of Science ID

WOS:000395511400056

Author(s)
Yan, Le
Ravasio, Riccardo  
Brito, Carolina
Wyart, Matthieu  
Date Issued

2017

Publisher

National Academy of Sciences

Published in
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)
Volume

114

Issue

10

Start page

2526

End page

2531

Subjects

disordered materials

•

proteins

•

evolution

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
PCSL  
Available on Infoscience
May 1, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/136843
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