Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. A Theoretical Analysis of the Geography of Schistosomiasis in Burkina Faso Highlights the Roles of Human Mobility and Water Resources Development in Disease Transmission
 
research article

A Theoretical Analysis of the Geography of Schistosomiasis in Burkina Faso Highlights the Roles of Human Mobility and Water Resources Development in Disease Transmission

Perez-Saez, Javier  
•
Mari, Lorenzo  
•
Bertuzzo, Enrico  
Show more
2015
PLOS Neglected Tropical Diseases

We study the geography of schistosomiasis across Burkina Faso by means of a spatially explicit model of water-based disease dynamics. The model quantitatively addresses the geographic stratification of disease burden in a novel framework by explicitly accounting for drivers and controls of the disease, including spatial information on the distributions of population and infrastructure, jointly with a general description of human mobility and climatic/ecological drivers. Spatial patterns of disease are analysed by the extraction and the mapping of suitable eigenvectors of the Jacobian matrix subsuming the stability of the disease-free equilibrium. The relevance of the work lies in the novel mapping of disease burden, a byproduct of the parametrization induced by regional upscaling, by model-guided field validations and in the predictive scenarios allowed by exploiting the range of possible parameters and processes. Human mobility is found to be a primary control at regional scales both for pathogen invasion success and the overall distribution of disease burden. The effects of water resources development highlighted by systematic reviews are accounted for by the average distances of human settlements from water bodies that are habitats for the parasite’s intermediate host. Our results confirm the empirical findings about the role of water resources development on disease spread into regions previously nearly disease-free also by inspection of empirical prevalence patterns. We conclude that while the model still needs refinements based on field and epidemiological evidence, the proposed framework provides a powerful tool for large-scale public health planning and schistosomiasis management.

  • Files
  • Details
  • Metrics
Type
research article
DOI
10.1371/journal.pntd.0004127
Web of Science ID

WOS:000364459600033

Author(s)
Perez-Saez, Javier  
Mari, Lorenzo  
Bertuzzo, Enrico  
Casagrandi, Renato
Sokolow, Susanne H.
De Leo, Giulio A.
Mande, Theophile  
Ceperley, Natalie  
Froehlich, Jean-Marc  
Sou, Mariam
Show more
Date Issued

2015

Publisher

Public Library of Science

Published in
PLOS Neglected Tropical Diseases
Volume

9

Issue

10

Article Number

e0004127

Subjects

schitosomiasis

•

spatial epidemiological modeling

•

stability analysis

•

Burkina Faso

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
ECHO  
Available on Infoscience
November 20, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/120719
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés