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research article

On the probability of extinction of the Haiti cholera epidemic

Bertuzzo, Enrico  
•
Finger, Flavio  
•
Mari, Lorenzo  
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2016
Stochastic Environmental Research and Risk Assessment

More than three years after its appearance in Haiti, cholera has already caused more than 8,500 deaths and 695,000 infections and it is feared to become endemic. However, no clear evidence of a stable environmental reservoir of pathogenic Vibrio cholerae, the infective agent of the disease, has emerged so far, suggesting the possibility that the transmission cycle of the disease is being maintained by bacteria freshly shed by infected individuals. Should this be the case, cholera could in principle be eradicated from Haiti. Here, we develop a framework for the estimation of the probability of extinction of the epidemic based on current information on epidemiological dynamics and health-care practice. Cholera spreading is modeled by an individual-based spatially-explicit stochastic model that accounts for the dynamics of susceptible, infected and recovered individuals hosted in different local communities connected through hydrologic and human mobility networks. Our results indicate that the probability that the epidemic goes extinct before the end of 2016 is of the order of 1 %. This low probability of extinction highlights the need for more targeted and effective interventions to possibly stop cholera in Haiti.

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Type
research article
DOI
10.1007/s00477-014-0906-3
Web of Science ID

WOS:000393196000002

Author(s)
Bertuzzo, Enrico  
Finger, Flavio  
Mari, Lorenzo  
Rinaldo, Andrea  
Gatto, Marino
Date Issued

2016

Publisher

Springer Verlag

Published in
Stochastic Environmental Research and Risk Assessment
Volume

30

Issue

8

Start page

2043

End page

2055

Subjects

epidemic cholera

•

spatially explicit modelling

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
ECHO  
Available on Infoscience
March 14, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/135312
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