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review article

The host defense of Drosophila melanogaster

Lemaitre, Bruno  
•
Hoffmann, Jules
2007
Annual review of immunology

To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense reactions, many of which are shared with higher organisms. These reactions include the use of physical barriers together with local and systemic immune responses. First, epithelia, such as those beneath the cuticle, in the alimentary tract, and in tracheae, act both as a physical barrier and local defense against pathogens by producing antimicrobial peptides and reactive oxygen species. Second, specialized hemocytes participate in phagocytosis and encapsulation of foreign intruders in the hemolymph. Finally, the fat body, a functional equivalent of the mammalian liver, produces humoral response molecules including antimicrobial peptides. Here we review our current knowledge of the molecular mechanisms underlying Drosophila defense reactions together with strategies evolved by pathogens to evade them.

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Type
review article
DOI
10.1146/annurev.immunol.25.022106.141615
Web of Science ID

WOS:000246437100024

PubMed ID

17201680

Author(s)
Lemaitre, Bruno  
Hoffmann, Jules
Date Issued

2007

Publisher

Annual Reviews

Published in
Annual review of immunology
Volume

25

Start page

697

End page

743

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPLEM  
Available on Infoscience
September 17, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/53795
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