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research article

Controlling morpho-electrophysiological variability of neurons with detailed models

Arnaudon, Alexis  
•
Reva, Maria  
•
Zbili, Mickael Maurice  
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October 30, 2023
Iscience

Variability, which is known to be a universal feature among biological units such as neuronal cells, holds significant importance, as, for example, it enables a robust encoding of a high volume of information in neuronal circuits and prevents hypersynchronizations. While most computational studies on electrophysiological variability in neuronal circuits were done with single-compartment neuron models, we instead focus on the variability of detailed biophysical models of neuron multi-compartmental morphologies. We leverage a Markov chain Monte Carlo method to generate populations of electrical models reproducing the variability of experimental recordings while being compatible with a set of morphologies to faithfully represent specifi morpho-electrical type. We demonstrate our approach on layer 5 pyramidal cells and study the morpho-electrical variability and in particular, find that morphological variability alone is insufficient to reproduce electrical variability. Overall, this approach provides a strong statistical basis to create detailed models of neurons with controlled variability.

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Type
research article
DOI
10.1016/j.isci.2023.108222
Web of Science ID

WOS:001101354300001

Author(s)
Arnaudon, Alexis  
Reva, Maria  
Zbili, Mickael Maurice  
Markram, Henry  
Van Geit, Werner  
Kanari, Lida  
Date Issued

2023-10-30

Publisher

Cell Press

Published in
Iscience
Volume

26

Issue

11

Article Number

108222

Subjects

Gabaergic Interneurons

•

Diversity

•

Compensation

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Conductances

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Degeneracy

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Modulation

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Simulation

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Variance

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Features

•

Impact

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
BBP-CORE  
FunderGrant Number

Swiss government's ETH Board of the Swiss Federal Institutes of Technology

Available on Infoscience
February 19, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/204278
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