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research article

Crystallization of undercooled liquid fenofibrate

Amstad, Esther  
•
Spaepen, Frans
•
Weitz, David A.
2015
Physical Chemistry Chemical Physics

Formulation of hydrophobic drugs as amorphous materials is highly advantageous as this increases their solubility in water and therefore their bioavailability. However, many drugs have a high propensity to crystallize during production and storage, limiting the usefulness of amorphous drugs. We study the crystallization of undercooled liquid fenofibrate, a model hydrophobic drug. Nucleation is the rate-limiting step; once seeded with a fenofibrate crystal, the crystal rapidly grows by consuming the undercooled liquid fenofibrate. Crystal growth is limited by the incorporation of molecules into its surface. As nucleation and growth both entail incorporation of molecules into the surface, this process likely also limits the formation of nuclei and thus the crystallization of undercooled liquid fenofibrate, contributing to the good stability of undercooled liquid fenofibrate against crystallization.

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Type
research article
DOI
10.1039/c5cp04958j
Web of Science ID

WOS:000364639700079

Author(s)
Amstad, Esther  
Spaepen, Frans
Weitz, David A.
Date Issued

2015

Publisher

Royal Society of Chemistry

Published in
Physical Chemistry Chemical Physics
Volume

17

Issue

44

Start page

30158

End page

30161

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SMAL  
Available on Infoscience
February 16, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/123701
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