Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. The Channel-Activating Protease CAP1/Prss8 Is Required for Placental Labyrinth Maturation
 
research article

The Channel-Activating Protease CAP1/Prss8 Is Required for Placental Labyrinth Maturation

Hummler, Edith
•
Dousse, Aline
•
Rieder, Audrey
Show more
2013
PLoS ONE

The serine protease CAP1/Prss8 is crucial for skin barrier function, lung alveolar fluid clearance and has been unveiled as diagnostic marker for specific cancer types. Here, we show that a constitutive knockout of CAP1/Prss8 leads to embryonic lethality. These embryos presented no specific defects, but it is during this period, and in particular at E13.5, that wildtype placentas show an increased expression of CAP1/Prss8, thus suggesting a placental defect in the knockout situation. The placentas of knockout embryos exhibited significantly reduced vascular development and incomplete cellular maturation. In contrary, epiblast-specific deletion of CAP1/Prss8 allowed development until birth. These CAP1/Prss8-deficient newborns presented abnormal epidermis, and died soon after birth due to impaired skin function. We thus conclude that a late placental insufficiency might be the primary cause of embryonic lethality in CAP1/Prss8 knockouts. This study highlights a novel and crucial role for CAP1/Prss8 in placental development and function.

  • Files
  • Details
  • Metrics
Type
research article
DOI
10.1371/journal.pone.0055796
Web of Science ID

WOS:000315153400159

Author(s)
Hummler, Edith
Dousse, Aline
Rieder, Audrey
Stehle, Jean-Christophe
Rubera, Isabelle
Osterheld, Maria-Chiara
Beermann, Friedrich  
Frateschi, Simona
Charles, Roch-Philippe
Date Issued

2013

Publisher

Public Library of Science

Published in
PLoS ONE
Volume

8

Issue

2

Article Number

e55796

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
GR-BEERMANN  
Available on Infoscience
February 7, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/88640
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés