Rapid access to oxindoles by the combined use of an Ugi four-component reaction and a microwave-assisted intramolecular Buchwald-Hartwig amidation reaction

Bonnaterre, Florence; Bois-Choussy, Michele; Zhu, Jieping

doi:10.1021/ol061755z

research article

Rapid access to oxindoles by the combined use of an Ugi four-component reaction and a microwave-assisted intramolecular Buchwald-Hartwig amidation reaction

Bonnaterre, Florence

•

Bois-Choussy, Michele

•

Zhu, Jieping

2006

Organic Letters

A two-step sequence involving an Ugi four-component reaction (Ugi-4CR) and a palladium-catalyzed intramol. amidation of aryl iodide has been developed for rapid access to functionalized oxindoles, e.g., I. Microwave heating was used to accelerate and to improve the efficiency of the intramol. Buchwald-Hartwig reaction. [on SciFinder (R)]