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  4. P450-mediated electrochemical sensing of drugs in human plasma for personalized therapy
 
conference paper

P450-mediated electrochemical sensing of drugs in human plasma for personalized therapy

Cavallini, Andrea  
•
Carrara, Sandro  
•
De Micheli, Giovanni  
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2010
Proceedings of the 6th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME)
6th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME)

Nowadays, the concept of personalized therapy gains momentum. Pharmacogenomics, which represents a first answer to these needs, has the drawback of neglecting some variations of therapy response due to non-genetic factors. The aim of this paper is to investigate the feasibility of a non-genetic approach to personalized therapy, via the point-of-care drug monitoring in biological fluids with electrochemical biosensors. The proposed biosensor is based on the use of P450 enzymes as probe molecules, thanks to their key role in human metabolism. Multiwalled carbon nanotubes are used to enhance biosensor sensitivity. Results show how the proposed system is capable to detect drug amounts within the corresponding pharmacological ranges in human serum.

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Type
conference paper
Author(s)
Cavallini, Andrea  
Carrara, Sandro  
De Micheli, Giovanni  
Erokhin, V.
Date Issued

2010

Published in
Proceedings of the 6th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME)
ISBN of the book

978-1-4244-7905-4

Start page

1

End page

4

Subjects

P450

•

personalized therapy

•

electrochemistry

•

human serum

Editorial or Peer reviewed

NON-REVIEWED

Written at

EPFL

EPFL units
LSI1  
Event nameEvent placeEvent date
6th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME)

Berlin, Germany

July 18-21, 2010

Available on Infoscience
November 4, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/56660
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