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Privacy-Preserving Processing of Raw Genomic Data

Ayday, Erman  
•
Raisaro, Jean Louis  
•
Hengartner, Urs
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2013

Geneticists prefer to store patients' aligned, raw genomic data, in addition to their variant calls (compact and summarized form of the raw data), mainly because of the immaturity of bioinformatic algorithms and sequencing platforms. Thus, we propose a privacy-preserving system to protect the privacy of aligned, raw genomic data. The raw genomic data of a patient includes millions of short reads, each comprised of between 100 and 400 nucleotides (genomic letters). We propose storing these short reads at a biobank in encrypted form. The proposed scheme enables a medical unit (e.g., a pharmaceutical company or a hospital) to privately retrieve a subset of the short reads of the patients (which include a definite range of nucleotides depending on the type of the genetic test) without revealing the nature of the genetic test to the biobank. Furthermore, the proposed scheme lets the biobank mask particular parts of the retrieved short reads if (i) some parts of the provided short reads are out of the requested range, or (ii) the patient does not give consent to some parts of the provided short reads (e.g., parts revealing sensitive diseases). We evaluate the proposed scheme to show the amount of unauthorized genomic data leakage it prevents. Finally, we implement the proposed scheme and assess its practicality.

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Type
report
Author(s)
Ayday, Erman  
Raisaro, Jean Louis  
Hengartner, Urs
Molyneaux, Adam  
Hubaux, Jean-Pierre  
Date Issued

2013

Total of pages

25

Subjects

Genomics

•

Privacy

•

Bioinformatics

•

Raw genomic data

Written at

EPFL

EPFL units
LDS  
Available on Infoscience
July 21, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/93429
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