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  4. Fluorescence and optical-resolution photoacoustic imaging through capillary waveguides
 
conference paper

Fluorescence and optical-resolution photoacoustic imaging through capillary waveguides

Stasio, Nicolino
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Shibukawa, Atsushi
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Papadopoulos, Ioannis N.
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Bifano, Tg
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Kubby, J
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2016
Adaptive Optics And Wavefront Control For Biological Systems Ii
Conference on Adaptive Optics and Wavefront Control for Biological Systems II

Endoscopy can be used to obtain high-resolution images at large depths in biological tissues. Usually endoscopic devices have a diameter ranging from 1 to few millimeters. Using digital phase conjugation, it is possible to adapt ultrathin multimode fibers to endoscopic purposes. Recently, we demonstrated that a 330 mu m diameter, water-filled silica capillary waveguide can guide high frequency ultrasound waves through a 3 cm thick fat layer, allowing optical resolution photoacoustic imaging. Here we demonstrate that using digital phase conjugation, the same water-filled capillary waveguide (3 cm long) can be used as an endoscopic probe to obtain both fluorescence and optical resolution photoacoustic imaging, with no optical or acoustic elements at the tip of the waveguide. We study the consequences of using digital phase conjugation combined with a capillary waveguide and we conclude with possible future improvements of our endoscopic approach.

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