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research article

Transportable hyperpolarized metabolites

Ji, Xiao  
•
Bornet, Aurelien  
•
Vuichoud, Basile  
Show more
2017
Nature Communications

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the short lifetime of the hyperpolarized magnetization (typically < 1 min), the polarization process must be carried out close to the point of use. Here we introduce a concept that markedly extends hyperpolarization lifetimes and enables the transportation of hyperpolarized metabolites. The hyperpolarized sample can thus be removed from the polarizer and stored or transported for use at remote MRI or NMR sites. We show that hyperpolarization in alanine and glycine survives 16 h storage and transport, maintaining overall polarization enhancements of up to three orders of magnitude.

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Type
research article
DOI
10.1038/ncomms13975
Web of Science ID

WOS:000391641900001

Author(s)
Ji, Xiao  
Bornet, Aurelien  
Vuichoud, Basile  
Milani, Jonas  
Gajan, David
Rossini, Aaron J.  
Emsley, Lyndon  
Bodenhausen, Geoffrey  
Jannin, Sami  
Date Issued

2017

Publisher

Nature Publishing Group

Published in
Nature Communications
Volume

8

Article Number

13975

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LRM  
LRMB  
Available on Infoscience
February 17, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/134537
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