Latest embedded bio-signal analysis applications, targeting low-power Wireless Body Sensor Nodes (WBSNs), present conflicting requirements. On one hand, bio-signal analysis applications are continuously increasing their demand for high computing capabilities. On the other hand, long-term signal processing in WBSNs must be provided within their highly constrained energy budget. In this context, parallel processing effectively increases the power efficiency of WBSNs, but only if the execution can be properly synchronized among computing elements. To address this challenge, in this work we propose a hardware/software approach to synchronize the execution of bio-signal processing applications in multi-core WBSNs. This new approach requires little hardware resources and very few adaptations in the source code. Moreover, it provides the necessary flexibility to execute applications with an arbitrarily large degree of complexity and parallelism, enabling considerable reductions in power consumption for all multi-core WBSN execution conditions. Experimental results show that a multi-core WBSN architecture using the illustrated approach can obtain energy savings of up to 40%, with respect to an equivalent singlecore architecture, when performing advanced bio-signal analysis