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  4. Study of the stability of the 5-aminolevulinic acid tyrosine ester in aqueous solution
 
research article

Study of the stability of the 5-aminolevulinic acid tyrosine ester in aqueous solution

Gay, S.  
•
Martoccia, C.  
•
Zellweger, Matthieu  
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2014
ARKIVOC - Online Journal of Organic Chemistry

Photodynamic therapy based on photoactivable porphyrins (PAPs) can treat various dermatological conditions. The side-effects as well as the non-selective or insufficient accumulation of PAPs in the targeted tissues limit performances. We studied the stability in solution at different temperatures (21 degrees C; 4 degrees C), different pH values (7.5; 2.0), and as a function of time of 5-aminolevulinic acid's Tyrosine-ester, a molecule presenting interesting properties to selectively produce PAPs in blood vessels after topical application. Solutions of this precursor can be kept up to 24 h at refrigerated temperatures and under acidic pH. At room temperature or physiological pH, they must be prepared minutes before their use.

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Type
research article
DOI
10.3998/ark.5550190.p008.469
Web of Science ID

WOS:000343046700016

Author(s)
Gay, S.  
Martoccia, C.  
Zellweger, Matthieu  
Wang, Q.
Wagnières, Georges  
Date Issued

2014

Published in
ARKIVOC - Online Journal of Organic Chemistry
Volume

2014

Issue

3

Start page

228

End page

238

Subjects

5-Aminolevulinic acid

•

stability

•

5-aminolevulinic acid derivatives

•

photodynamic therapy

•

tyrosine ester

URL

URL

http://p3.snf.ch/publication-a3707398-810e-4e92-bebe-ddccb6b80989
Editorial or Peer reviewed

REVIEWED

Written at

EPFL

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GR-VDB  
LCOM  
Available on Infoscience
January 27, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/100179
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