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  4. Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field
 
research article

Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field

Patil, Nirbhay
•
Bonneau, Stéphanie
•
Joubert, Fréderic
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August 5, 2020
Physical Review E

As the places where most of the fuel of the cell, namely, ATP, is synthesized, mitochondria are crucial organelles in eukaryotic cells. The shape of the invaginations of the mitochondria inner membrane, known as a crista, has been identified as a signature of the energetic state of the organelle. However, the interplay between the rate of ATP synthesis and the crista shape remains unclear. In this work, we investigate the crista membrane deformations using a pH-dependent Helfrich model, maintained out of equilibrium by a diffusive flux of protons. This model gives rise to shape changes of a cylindrical invagination, in particular to the formation of necks between wider zones under variable, and especially oscillating, proton flux.

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Type
research article
DOI
10.1103/PhysRevE.102.022401
ArXiv ID

arXiv:1912.06373v2

Author(s)
Patil, Nirbhay
Bonneau, Stéphanie
Joubert, Fréderic
Bitbol, Anne-Florence
Berthoumieux, Hélène
Date Issued

2020-08-05

Published in
Physical Review E
Volume

102

Issue

2

Article Number

022401

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPBITBOL  
Available on Infoscience
August 16, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/170889
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