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research article

Population structure determines the tradeoff between fixation probability and fixation time

Tkadlec, Josef
•
Pavlogiannis, Andreas  
•
Chatterjee, Krishnendu
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April 23, 2019
Communications Biology

The rate of biological evolution depends on the fixation probability and on the fixation time of new mutants. Intensive research has focused on identifying population structures that augment the fixation probability of advantageous mutants. But these amplifiers of natural selection typically increase fixation time. Here we study population structures that achieve a tradeoff between fixation probability and time. First, we show that no amplifiers can have an asymptotically lower absorption time than the well-mixed population. Then we design population structures that substantially augment the fixation probability with just a minor increase in fixation time. Finally, we show that those structures enable higher effective rate of evolution than the well-mixed population provided that the rate of generating advantageous mutants is relatively low. Our work sheds light on how population structure affects the rate of evolution. Moreover, our structures could be useful for lab-based, medical, or industrial applications of evolutionary optimization.

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Type
research article
DOI
10.1038/s42003-019-0373-y
Web of Science ID

WOS:000465425700006

Author(s)
Tkadlec, Josef
Pavlogiannis, Andreas  
Chatterjee, Krishnendu
Nowak, Martin A.
Date Issued

2019-04-23

Publisher

Springer

Published in
Communications Biology
Volume

2

Start page

138

Subjects

Biology

•

Multidisciplinary Sciences

•

Life Sciences & Biomedicine - Other Topics

•

Science & Technology - Other Topics

•

evolutionary dynamics

•

clonal interference

•

mutant

•

adaptation

•

mutations

•

models

Note

This article is licensed under a Creative Commons Attribution 4.0 International License

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LARA  
Available on Infoscience
June 18, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/157441
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