Light induces important “Non-Image-Forming” (NIF) effects on human physiology and behavior, such as improvement of alertness, cognitive performance and mood. Considering these effects in office lighting can improve well-being and productivity of the occupants. This study introduces and evaluates NIF effects of light on humans within a Building Automation System of an office environment. Real-time luminance mapping is assessed by novel HDR vision sensors; the monitored data is used for a smart user-centric controller of the indoor electric lighting and sun shadings. A preliminary evaluation of this advanced controller was carried out during one week in a single-occupied office in the LESO solar experimental building at the Swiss Federal Institute of Technology (EPFL) in Lausanne, Switzerland. The system demonstrated to have sound capabilities in satisfying visual comfort conditions and well-being for the office's occupant.