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research article

Element- and enantiomer-selective visualization of molecular motion in real-time

Mincigrucci, R.
•
Rouxel, J. R.
•
Rossi, B.
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January 24, 2023
Nature Communications

Ultrafast optical-domain spectroscopies allow to monitor in real time the motion of nuclei in molecules. Achieving element-selectivity had to await the advent of time resolved X-ray spectroscopy, which is now commonly carried at X-ray free electron lasers. However, detecting light element that are commonly encountered in organic molecules, remained elusive due to the need to work under vacuum. Here, we present an impulsive stimulated Raman scattering (ISRS) pump/carbon K-edge absorption probe investigation, which allowed observation of the low-frequency vibrational modes involving specific selected carbon atoms in the Ibuprofen RS dimer. Remarkably, by controlling the probe light polarization we can preferentially access the enantiomer of the dimer to which the carbon atoms belong.

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Type
research article
DOI
10.1038/s41467-023-36047-5
Web of Science ID

WOS:001170148000009

Author(s)
Mincigrucci, R.
Rouxel, J. R.
Rossi, B.
Principi, E.
Bottari, C.
Catalini, S.
Pelli-Cresi, J. S.
Fainozzi, D.
Foglia, L.
Simoncig, A.
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Date Issued

2023-01-24

Publisher

Nature Portfolio

Published in
Nature Communications
Volume

14

Issue

1

Start page

386

Subjects

X-Ray-Absorption

•

Photoinduced Structural Dynamics

•

Sum-Frequency Generation

•

Circular-Dichroism

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Polarization Control

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Racemic Ibuprofen

•

Raman-Scattering

•

Spectroscopy

•

Spectra

•

Phase

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LSU  
FunderGrant Number

Swiss NSF via the NCCR:MUST

European Research Council Advanced H2020 Grant

ERCEA 695197 DYNAMOX

National Science Foundation

CHE-1953045

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Available on Infoscience
April 3, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/206817
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