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review article

Bacterial pore-forming toxins: the (w)hole story?

Gonzalez, M. R.  
•
Bischofberger, M.  
•
Pernot, L.
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2008
Cellular and Molecular Life Sciences

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response to this threat. Recent studies reveal that cells do not just swell and lyse, but are able to sense and react to pore formation, mount a defense, even repair the damaged membrane and thus survive. These responses involve a variety of signal-transduction pathways and sophisticated cellular mechanisms such as the pathway regulating lipid metabolism. In this review we discuss the different classes of bacterial PFTs and their modes of action, and provide examples of how the different bacteria use PFTs. Finally, we address the more recent field dealing with the eukaryotic cell response to PFT-induced damage

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Type
review article
DOI
10.1007/s00018-007-7434-y
Web of Science ID

WOS:000252941100010

Author(s)
Gonzalez, M. R.  
Bischofberger, M.  
Pernot, L.
van der Goot, F. G.  
Frêche, B.
Date Issued

2008

Publisher

Birkhäuser-Verlag, Springer

Published in
Cellular and Molecular Life Sciences
Volume

65

Issue

3

Start page

493

End page

507

Note

Author address: Ecole Polytechnique Fédérale de Lausanne, Global Health Institute, Station 15, 1015 Lausanne, Switzerland

National Licences

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
VDG  
Available on Infoscience
February 2, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/34709
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