This work reports the outcomes of an extensive experimental campaign on the retrofitting of masonry walls by means of carbon fiber reinforced polymer (CFRP) sheets, carried out at University of Applied Sciences (UAS) Fribourg. In the first stage, static-cyclic shear tests were conducted on the masonry walls, followed by a second stage of tensile tests on alternative configurations of mechanical anchorage so as to assess the effects on the structural response and to identify the associated limits. In the static-cyclic shear tests, it was found that the resistance of masonry walls retrofitted with CFRP sheets was improved by up to 70%, and the deformability was improved by up to 10% in comparison to the un-retrofitted specimens. The experimental tests conducted on alternate configurations of mechanical anchorages indicate that the tested materials and configurations rely heavily on details. The sensitivity of CFRP sheets to edges, non-uniformities on any adherend, and bonding defects can cause premature CFRP failure and, hence, pose problems for the efficient design of a retrofitting scheme. As indicated by the results of this investigation, effective anchorage can be achieved when eccentric loading of the mechanical anchorage is avoided and a smooth bonding surface is guaranteed.