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  4. Time-Resolved NIROT 'Pioneer' System for Imaging Oxygenation of the Preterm Brain: Preliminary Results
 
conference paper

Time-Resolved NIROT 'Pioneer' System for Imaging Oxygenation of the Preterm Brain: Preliminary Results

Di Costanzo-Mata, A.
•
Jiang, J.
•
Lindner, S.
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January 1, 2020
Oxygen Transport To Tissue Xli
46th Annual Meeting of the International-Society-on-Oxygen-Transport-to-Tissue (ISOTT)

In preterm infants, there is a risk of long-term cognitive, motor and behavioral impairments due to hemorrhagic and/or ischemic lesions. If detected early, lesions can be prevented. A bedside imaging modality, capable of early detection of both disorders, is necessary. We present the state of development of a tomographic imager (named Pioneer), that will be capable of determining the oxygenation of the preterm-infant brain with high spatial resolution. Pioneer is a time-resolved near-infrared optical tomography (TR NIROT) instrument. It employs multiple wavelength laser light in short pulses on 11 distinct locations and measures the reemerging light in a con tactless fashion by means of a time-correlated single-photon counting (TCSPC) camera (named Piccolo) covering similar to 4.9 cm(2) with 300 detectors. Timing response of the entire system is 116 ps. An in-house designed biocompatible source ring ensures fixed relative positions of sources and detectors and provides a secure interface between the patient and the probe. At the present state, the NIROT Pioneer system successfully detected a 6x6x50 mm(3) inclusion 3 cm deep inside a phantom. These results confirm that the Pioneer imager is working as expected and is on a solid path towards full 3D tissue oxygenation imaging.

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Type
conference paper
DOI
10.1007/978-3-030-34461-0_44
Web of Science ID

WOS:000554927500044

Author(s)
Di Costanzo-Mata, A.
Jiang, J.
Lindner, S.
Ahnen, L.
Zhang, C.  
Sanchez-Majos, S.
Wolf, M.
Charbon, E.  
Kalyanov, A.
Date Issued

2020-01-01

Publisher

SPRINGER INTERNATIONAL PUBLISHING AG

Publisher place

Cham

Published in
Oxygen Transport To Tissue Xli
ISBN of the book

978-3-030-34461-0

978-3-030-34459-7

Series title/Series vol.

Advances in Experimental Medicine and Biology

Volume

1232

Start page

347

End page

354

Subjects

Medicine, Research & Experimental

•

Research & Experimental Medicine

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
ICLAB  
AQUA  
Event nameEvent placeEvent date
46th Annual Meeting of the International-Society-on-Oxygen-Transport-to-Tissue (ISOTT)

Seoul, SOUTH KOREA

Jul 01-05, 2018

Available on Infoscience
August 13, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/170822
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