review article
Hepatitis C pharmacogenetics: state of the art in 2010
2011
In 2009, a correlated set of polymorphisms in the region of the interleukin-28B (IL28B) gene were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with pegylated interferon-alfa and ribavirin. The same polymorphisms were subsequently associated with spontaneous clearance of HCV in untreated patients. The link between IL28B genotype and HCV clearance may impact decisions regarding initiation of current therapy, the design and interpretation of clinical studies, the economics of treatment, and the process of regulatory approval for new anti-HCV therapeutic agents.
Type
review article
Author(s)
Afdhal, Nezam H.
McHutchison, John G.
Zeuzem, Stefan
Mangia, Alessandra
Pawlotsky, Jean-Michel
Murray, Jeffrey S.
Shianna, Kevin V.
Tanaka, Yasuhito
Thomas, David L.
Booth, David R.
Date Issued
2011
Published in
Volume
53
Issue
1
Start page
336
End page
45
Editorial or Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
April 11, 2011
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