MP2RAGE, a self bias-field corrected sequence for improved segmentation and T-1-mapping at high field

Marques, Jose P.; Kober, Tobias; Krueger, Gunnar; van der Zwaag, Wietske; Van de Moortele, Pierre-Francois; Gruetter, Rolf

doi:10.1016/j.neuroimage.2009.10.002

research article

MP2RAGE, a self bias-field corrected sequence for improved segmentation and T-1-mapping at high field

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2010

The large spatial inhomogeneity in transmit B, field (B-1(+)) observable in human MR images at hi h static magnetic fields (B-0) severely impairs image quality. To overcome this effect in brain T-1-weighted images the, MPRAGE sequence was modified to generate two different images at different inversion times MP2RAGE By combining the two images in a novel fashion, it was possible to create T-1-weigthed images where the result image was free of proton density contrast, T-2* contrast, reception bias field, and, to first order transmit field inhomogeneity.