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research article

Orthopedic implant used as drug delivery system: clinical situation and state of the research

Pioletti, Dominique P.  
•
Gauthier, Olivier
•
Stadelmann, Vincent A.
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2008
Current Drug Delivery

A partial review is proposed on the existing literature for the research performed in orthopedic implant used as drug delivery system. In the first part an evaluation is given on the clinical need to deliver a drug in the surrounding of an implant. Secondly, a review of the clinical situation is developed for implants already used as drug delivery system. Experimental works performed for local delivery are reported. In particular, a description is given on the in vitro and in vivo studies where the implant is coated with different proteins or drugs. Finally, a conclusion is proposed on the next step in the development of orthopedic implant as drug delivery system mentioning also the industrial situation.

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Type
research article
Author(s)
Pioletti, Dominique P.  
Gauthier, Olivier
Stadelmann, Vincent A.
Bujoli, Bruno
Guicheux, Jérôme
Zambelli, Pierre-Yves
Bouler, Jean-Michel Bouler
Date Issued

2008

Published in
Current Drug Delivery
Volume

5

Start page

59

End page

63

Subjects

Orthopedic implant

•

Local delivery

•

Drug

•

Bone remodeling

Note

Review

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LBO  
Available on Infoscience
August 22, 2007
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/10416
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