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  4. How to improve the efficiency of a traditional dissolution dynamic nuclear polarization (dDNP) apparatus: Design and performance of a fluid path compatible dDNP/LOD-ESR probe
 
research article

How to improve the efficiency of a traditional dissolution dynamic nuclear polarization (dDNP) apparatus: Design and performance of a fluid path compatible dDNP/LOD-ESR probe

Lê, Thanh Phong  
•
Hyacinthe, Jean-Noël  
•
Capozzi, Andrea  
March 26, 2022
Journal of Magnetic Resonance

Dissolution Dynamic Nuclear Polarization (dDNP) was invented almost twenty years ago. Ever since, hardware advancement has observed 2 trends: the quest for DNP at higher field and, more recently, the development of cryogen free polarizers. Despite the DNP community is slowly migrating towards “dry” systems, many “wet” polarizers are still in use. Traditional DNP polarizers can use up to 100 L of liquid helium per week, but are less sensitive to air contamination and have higher cooling power. These two characteristics make them very versatile when it comes to new methods development. In this study we retrofitted a 5 T/1.15 K “wet” DNP polarizer with the aim of improving cryogenic and DNP performance. We designed, built, and tested a new DNP insert that is compatible with the fluid path (FP) technology and a LOgitudinal Detected Electron Spin Resonance (LOD-ESR) probe to investigate radical properties at real DNP conditions. The new hardware increased the maximum achievable polarization and the polarization rate constant of a [1-13C]pyruvic acid-trityl sample by a factor 1.5. Moreover, the increased liquid He holding time together with the possibility to constantly keep the sample space at low pressure upon sample loading and dissolution allowed us to save about 20 L of liquid He per week.

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Type
research article
DOI
10.1016/j.jmr.2022.107197
Author(s)
Lê, Thanh Phong  

EPFL

Hyacinthe, Jean-Noël  

EPFL

Capozzi, Andrea  

EPFL

Date Issued

2022-03-26

Publisher

Academic Press Inc - Elsevier Science

Published in
Journal of Magnetic Resonance
Volume

338

Article Number

107197

Subjects

Hyperpolarization

•

dDNP

•

Fluid path

•

LOD-ESR

•

Heat conduction at cryogenic temperatures

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LIFMET  
FunderGrant Number

FNS

CRSK-2_190547

FNS

PZ00P2_193276

FNS

310030_170155

Available on Infoscience
March 26, 2022
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/186575
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