For the dimensioning and assessment of structures, it is common practice to compare action effects with sectional resistances. Extensive studies have been performed to quantify the model uncertainty on the resistance side. However, for statically indeterminate systems, the model uncertainty in the calculation of action effects has not been properly investigated yet. The aim of this article is to contribute in quantifying the model uncertainty in action effects and load bearing capacity calculations for reinforced concrete structures, accounting for the type of mechanical model used and for various failure modes. To collect a sufficient amount of data and perform statistical analyses, the experimental response of statically indeterminate systems is obtained with a simple and effective technique which allows using experimental results available in literature. Finally, on the basis of a parametric analysis and case studies, practical implications are discussed and recommendations are given concerning the implementation in the partial safety factor format.