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  4. A Minimal Exercise Extension for Models of the Glucoregulatory System
 
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conference paper

A Minimal Exercise Extension for Models of the Glucoregulatory System

Bock, Alain  
•
François, Grégory  
•
Prud'homme, Thierry
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Pistikopoulos, E. N.
•
Georgiadis, M. C.
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2011
21st European Symposium on Computer Aided Process Engineering - ESCAPE 21
21st European Symposium on Computer Aided Process Engineering - ESCAPE 21

For patients with type 1 diabetes mellitus, appropriate control of blood glucose concentrations is vital. Exercise is one of the disturbances that can affect these concentrations. Therefore, predictions in the presence of exercise are useful among others for model-based control methods, bolus calculators and educational tools. Although several models quantifying the effect of exercise are available, they generally include a high number of model parameters, which makes the identification a particularly challenging task, especially if only blood glucose measurements are available. In this paper, a new data-based minimal extension for existing models of the glucoregulatory system, which is able to account for the effect of exercise, is proposed. As observed from clinical data, for given exercise intensities and durations, the model does not depend on exercise intensity, making intensity measurements obsolete. Another main advantage is that this minimal extension involves the identification of only two additional scalar model parameters. The resulting model shows good agreement with the clinical data, and the obtained parameters are consistent between patients.

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Type
conference paper
DOI
10.1016/B978-0-444-54298-4.50083-0
Web of Science ID

WOS:000294218900304

Author(s)
Bock, Alain  
•
François, Grégory  
•
Prud'homme, Thierry
•
Gillet, Denis  
Editors
Pistikopoulos, E. N.
•
Georgiadis, M. C.
•
Kokossis, A. C.
Date Issued

2011

Publisher

Elsevier

Publisher place

Oxford, U.K.

Published in
21st European Symposium on Computer Aided Process Engineering - ESCAPE 21
ISBN of the book

978-0-444-53711-9

Series title/Series vol.

Computer-Aided Chemical Engineering, 29

Volume

A

Start page

1520

End page

1524

Subjects

Type 1 Diabetes Mellitus

•

Dynamical Model Extension

•

Exercise

•

Biomedical Systems

URL

URL

http://www.escape-21.gr/
Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
REACT  
LA  
Event nameEvent placeEvent date
21st European Symposium on Computer Aided Process Engineering - ESCAPE 21

Chalkidiki, Greece

May 29 - June 1, 2011

Available on Infoscience
November 19, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/57990
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