Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Patents
  4. Method to extract and use time-resolved ion clouds from a spectrometric data set
 
patent

Method to extract and use time-resolved ion clouds from a spectrometric data set

Koolen, Cedric David  
•
Koolen, Sven R.J
2025

A method is proposed for extracting single-particle and/or single-cell events from a spectrometric data set comprising intensity values. A respective intensity value is proportional to the number of ions collected by a detector in a given time interval. The method comprises: grouping (22) the intensity values into sets of groups of consecutive intensity values, a respective set being <b>characterised by</b> a distinct group size of consecutive intensity values; determining (23) a threshold value separating a background from candidate event intensity values; calculating (24) a dissolved intensity as a mean of the intensity values forming a background signal; carrying out (25) a first candidate event identification by obtaining candidate peak groups based on a feature characterising a respective group; carrying (26) out a second candidate event identification by obtaining ion cloud groups based on the threshold value; carrying out (27) a true event identification by comparing the first and second candidate event identifications to obtain one or more ion cloud group events for a respective group size; and summing (28) the intensity values of a respective ion cloud group event and subtracting the dissolved intensity as scaled from the summed intensity values of the respective ion cloud group event to obtain a total intensity value per particle or cell.

  • Details
  • Metrics
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés