Protein synthesis- and fucosylation-dependent mechanisms in corticosterone facilitation of long-term memory in the chick

Long-term memory formation for a passive avoidance task in day-old chicks, which requires a late phase of glycoprotein fucosylation (5-8 hr posttraining), is dependent on a corticosterone action in the brain. In addition, corticosterone enhances late-phase fucosylation. In this study, the authors explored (a) to what extent the memory-facilitating action of corticosterone is dependent on protein fucosylation and (b) whether a protein synthesis mechanism might be involved in the steroid effects on memory and late-phase fucosylation. A combination of psychopharmacological and biochemical experiments, including the fucosylation inhibitor 2-deoxygalactose (2-DG), the protein synthesis inhibitor anisomycin (ANI), and radiolabeled fucose, indicated that the late phase of glycoprotein synthesis involved in the memory-facilitating effect of corticosterone occurs on newly synthesized proteins.


Published in:
Behav Neurosci, 111, 5, 1098-104
Year:
1997
ISSN:
0735-7044
Keywords:
Note:
Author address: Behavior Research Group, Open University, Milton Keynes, United Kingdom. csandi@cu.uned.es
Laboratories:




 Record created 2007-01-18, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)