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  4. Notch signaling in T- and B-cell development
 
research article

Notch signaling in T- and B-cell development

Radtke, F.  
•
Wilson, A.
•
MacDonald, H. R.
2004
Current Opinion in Immunology

The Notch family of evolutionarily conserved proteins regulates a broad spectrum of cell-fate decisions and differentiation processes during fetal and post-natal development. The best characterized role of Notch signaling during mammalian hematopoiesis and lymphopoiesis is the essential function of the Notch1 receptor in T-cell lineage commitment. More recent studies have addressed the roles of other Notch receptors and ligands, as well as their downstream targets, revealing additional novel functions of Notch signaling in intra-thymic T-cell development, B-cell development and peripheral T-cell function.

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Type
research article
DOI
10.1016/j.coi.2004.01.002
PubMed ID

15023410

Author(s)
Radtke, F.  
Wilson, A.
MacDonald, H. R.
Date Issued

2004

Published in
Current Opinion in Immunology
Volume

16

Issue

2

Start page

174

End page

9

Subjects

Animals

•

B-Lymphocytes/*physiology

•

Cell Lineage

•

Gene Expression Regulation

•

Developmental

•

Membrane Proteins/*metabolism

•

Mice

•

Mice

•

Transgenic

•

Models

•

Biological

•

Receptors

•

Notch

•

Research Support

•

Non-U.S. Gov't

•

Signal Transduction

•

T-Lymphocytes/*physiology

Note

The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. Freddy.Radtke@isrec.unil.ch

Journal Article

Review

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPRAD  
Available on Infoscience
December 5, 2006
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/237318
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