The role of Notch signaling during hematopoietic lineage commitment
Over the last few years a vast amount of progress has been made in identifying mechanisms controlling lineage commitment and plasticity of hematopoietic precursors to different lymphoid or myeloid lineages. This has been due largely to the ability to identify and isolate rare cell populations in order to investigate their developmental potential, together with the development of inducible and/or tissue specific targeting technology. One family of proteins that has been postulated to be involved in hematopoietic stem cell maintenance as well as in multiple commitment processes during T cell development is the Notch receptors and their ligands. In this review we will summarize recent findings and controversies regarding the role of Notch signaling in the myeloid and lymphoid systems.
- URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12366683
Keywords: Animals ; *Cell Differentiation ; *Cell Lineage ; *Hematopoiesis ; Humans ; Lymphocytes/cytology/metabolism ; Membrane Proteins/*metabolism ; Myeloid Cells/cytology/metabolism ; Receptors ; Notch ; *Signal Transduction
The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland. Freddy.Radtke@isrec.unil.ch
Record created on 2006-12-05, modified on 2016-08-08