Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage
The developmental origin of dendritic cells (DCs) is controversial. In the mouse CD8alpha(+) and CD8alpha(-) DC subsets are often considered to be of lymphoid and myeloid origin respectively, although evidence on this point is conflicting. Very recently a novel CD11c(+) B220(+) DC subset has been identified that appears to be the murine counterpart to interferon alpha (IFNalpha)-producing human plasmacytoid DCs (PDCs). We show here that CD11c(+) B220(+) mouse PDCs, like human PDCs, are present in the thymus and express T lineage markers such as CD8alpha and CD4. However, the intrathymic development of PDCs can be completely dissociated from immature T lineage cells in mixed chimeras established with bone marrow cells from mice deficient for either Notch-1 or T-cell factor 1, two independent mutations that severely block early T-cell development. Our data indicate that thymic PDCs do not arise from a bipotential T/DC precursor.
- URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12351395
Keywords: Animals ; Antigens ; CD11c/*blood ; Antigens ; CD45/*blood ; Bone Marrow Cells/cytology/physiology ; Chimera/immunology ; Dendritic Cells/*immunology ; Humans ; Mice ; Mice ; Inbred C57BL ; Models ; Animal ; Research Support ; Non-U.S. Gov't ; T-Lymphocytes/*immunology
Ludwig Institute for Cancer Research, Lausanne Branch, and the World Health Organization (WHO) Immunology Research and Training Center, Institute of Biochemistry, University of Lausanne, Switzerland.
Record created on 2006-12-05, modified on 2016-08-08