Notch1 and T-cell development: insights from conditional knockout mice

• Published in: Trends Immunol, vol. 22, num. 3, p. 155-60
• Publication date: 2001

Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, alphabeta/gammadelta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene.

Keywords: Animals ; B-Lymphocytes/cytology/immunology ; CD4-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/cytology ; Cell Differentiation ; Cell Lineage ; Membrane Proteins/genetics/*physiology ; Mice ; Mice ; Knockout ; Receptor ; Notch1 ; Receptors ; Antigen ; T-Cell ; alpha-beta ; Receptors ; Antigen ; T-Cell ; gamma-delta ; *Receptors ; Cell Surface ; Signal Transduction/physiology ; T-Lymphocytes/*cytology/immunology ; *Transcription Factors

Note:

The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066, Epalinges, Switzerland. hughrobson.macdonald@isrec.unil.ch

1471-4906 (Print)

Journal Article

Review

Reference

• UPRAD-ARTICLE-2001-002
• URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11286731

Record created on 2006-12-05, modified on 2017-05-12