Notch1 and T-cell development: insights from conditional knockout mice
Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, alphabeta/gammadelta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene.
- URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11286731
Keywords: Animals ; B-Lymphocytes/cytology/immunology ; CD4-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/cytology ; Cell Differentiation ; Cell Lineage ; Membrane Proteins/genetics/*physiology ; Mice ; Mice ; Knockout ; Receptor ; Notch1 ; Receptors ; Antigen ; T-Cell ; alpha-beta ; Receptors ; Antigen ; T-Cell ; gamma-delta ; *Receptors ; Cell Surface ; Signal Transduction/physiology ; T-Lymphocytes/*cytology/immunology ; *Transcription Factors
The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066, Epalinges, Switzerland. email@example.com
Record created on 2006-12-05, modified on 2016-08-08