Notch1 and T-cell development: insights from conditional knockout mice

Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, alphabeta/gammadelta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene.


Published in:
Trends Immunol, 22, 3, 155-60
Year:
2001
Keywords:
Note:
The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066, Epalinges, Switzerland. hughrobson.macdonald@isrec.unil.ch
1471-4906 (Print)
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 Record created 2006-12-05, last modified 2018-03-17

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