Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Notch1 and T-cell development: insights from conditional knockout mice
 
research article

Notch1 and T-cell development: insights from conditional knockout mice

MacDonald, H. R.
•
Wilson, A.
•
Radtke, F.  
2001
Trends in Immunology

Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, alphabeta/gammadelta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene.

  • Details
  • Metrics
Type
research article
DOI
10.1016/S1471-4906(00)01828-7
PubMed ID

11286731

Author(s)
MacDonald, H. R.
Wilson, A.
Radtke, F.  
Date Issued

2001

Published in
Trends in Immunology
Volume

22

Issue

3

Start page

155

End page

160

Subjects

Animals

•

B-Lymphocytes/cytology/immunology

•

CD4-Positive T-Lymphocytes/cytology

•

CD8-Positive T-Lymphocytes/cytology

•

Cell Differentiation

•

Cell Lineage

•

Membrane Proteins/genetics/*physiology

•

Mice

•

Mice

•

Knockout

•

Receptor

•

Notch1

•

Receptors

•

Antigen

•

T-Cell

•

alpha-beta

•

Receptors

•

Antigen

•

T-Cell

•

gamma-delta

•

*Receptors

•

Cell Surface

•

Signal Transduction/physiology

•

T-Lymphocytes/*cytology/immunology

•

*Transcription Factors

Note

The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066, Epalinges, Switzerland. hughrobson.macdonald@isrec.unil.ch

Journal Article

Review

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPRAD  
Available on Infoscience
December 5, 2006
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/237304
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés