Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway

The Nedd8 ubiquitin-like protein modification pathway regulates cell-cycle progression. Our analysis of Nedd8 requirements during Caenorhabditis elegans embryogenesis indicates that the cytoskeleton is another target. Nedd8 conjugation negatively regulated contractility of the microfilament-rich cell cortex during pronuclear migration and again during cytokinesis. The Nedd8 pathway also was required after meiosis to negatively regulate katanin, a microtubule-severing complex, permitting the assembly of a large mitotic spindle. We propose that Nedd8-modified cullin, as part of an E3 ubiquitin ligase complex, targets katanin for degradation during the transition from meiosis to mitosis.


Published in:
Science, 295, 5558, 1294-8
Year:
2002
Keywords:
Note:
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
1095-9203 (Electronic)
Journal Article
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 Record created 2006-08-24, last modified 2018-01-27

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