Cortical domains and the mechanisms of asymmetric cell division

Asymmetric cell divisions are central to the generation of cell-fate diversity because factors that are present in a mother cell and distributed unequally at cell division can generate distinct daughters. The process o f asymmetric cell division can be described as consisting of three steps: setting up an asymmetric cue in the mother cell, localizing factors with respect to this cue, and positioning the plane o f cell division so that localized factors are partitioned asymmetrically between daughters. This review describes how specialized cortical domains play a key role in each of these steps and discusses our current understanding of the molecular nature o f cortical domains and the mechanisms by which they may orchestrate asymmetric cell divisions.

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Trends Cell Biol, 6, 10, 382-7
Cell Biology Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. Gönczy@EMBL-Heidelberg.DE
0962-8924 (Print)
Journal Article

 Record created 2006-08-24, last modified 2018-03-17

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